"50400: Gateway Timeout." in BizTalk services for large XML files

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"50400: Gateway Timeout." in BizTalk services for large XML files

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As a general rule BizTalk is not SSIS, BizTalk is not an ETL (Extract, Transform and Load), BizTalk is not meant to insert thousand and thousand of rows at one time.

Try to chunk your file in little part and process say 10 at a time. (BatchSize=10)

If you really can't do this and want continue with this solution increase your send timeout property available in WCF-CUSTOM or WCF-SQL adapter Configuration.