I have this problem quite frequently on my Macbook Pro.
Steps to reproduce:
- Open any project on Android studio
- Connect a mobile device to my computer via USB
- Click on the run button
At this stage, the green "run" button turns to grey but nothing goes on underneath. No Gradle build running or any similar notification. Any attempt to Build project or Clean project does not work. I also noticed that the Gradle pane at the right side of the screen is never visible every time this happens.
Usually, restarting my Android studio fixes this issue but I want to know if there is a permanent solution to this.
Go to File and try Invalidate Cache/Restart. It will work.