Changed .NET target and my solution won't open

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I changed my target to NET4.5 to accommodate a library I'm embedding and now my solution won't open properly. VS seems to think that it's open, but I cannot change solution/project settings or properties, and none of my solution data is available in the explorer. Any thoughts on what I can do?

After I changed it, VS said that the solution needed to be closed and reopened. Then it never reopened.

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