CNN for Brain Tumour Detection using 3D MRI images

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I am looking to implement a CNN to detect Alzheimer disease using 3D MRI dataset containing healthy and diseased samples. I am getting a very low efficiency using LeNet and VGG16. My models aren't learning and I have around 300 images total. I am trying 3D as well as 2D convolution.

The main problem is handling the 3D images. Please do help

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