Error Code: 502 Proxy Error. The ISA Server denied the specified Uniform Resource Locator (URL). (12202)

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I am getting above error in some machines but not in some machines while accessing the documents.

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More information in your question might help, but after a quick google I found this forum which may answer your question (there appears to be a hotfix that may help).

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Open the ISA server2006 and create a role and allow networks internal to allow internal and external.

Restart isa services, and it will be work fine.