How can better Python-GUI be built?

Question

Very new tho this GUI, trying to build python-GUI. have designed GUI structure from wx-form builder and using the same. I have just created two drop-downs and two buttons. As you select two drop-down values and click start button,

1) It should display what values are selected.
2) `Start` button should be freezed, till some activity completed.
3) `Start` button should be released when some activity is completed or when `Stop` button is clicked.
4) And also, Is it possible to select multiple values from drop-down ?

I'm not sure what i've tried is right. Bur will post the code below here, please guide me through this. And also if any good document, please help me.

test.py

import wx
from wx import xrc


class MyApp(wx.App):

    def OnInit(self):
        self.res = xrc.XmlResource('test.xrc')
        self.init_frame()
        return True

    def init_frame(self):
        self.frame = self.res.LoadFrame(None, 'mainFrame')
        #text = str(combobox1.currentText())
        self.env = xrc.XRCCTRL(self.frame, 'list1')
        self.service = xrc.XRCCTRL(self.frame, 'list2')
        #self.panel = xrc.XRCCTRL(self.frame, 'panel')
        #self.text1 = xrc.XRCCTRL(self.panel, 'text1')
        #self.text2 = xrc.XRCCTRL(self.panel, 'text2')
        self.frame.Bind(wx.EVT_BUTTON, self.OnSubmit, id=xrc.XRCID('Button1'))
        self.frame.Show()

    def OnSubmit(self,a):
        wx.MessageBox('Your name is %s %s!' %
            (self.env, self.service), 'Feedback')
        #print self.env
        #self.service = xrc.XRCCTRL(self.panel, 'serviceList')
        #self.frame.Bind(wx.EVT_BUTTON, self.OnNewFrame, self.button)
        self.frame.Show()

        # self.collectLogButton.Bind( wx.EVT_BUTTON, self.solveFunc )
#       self.stopButton.Bind( wx.EVT_BUTTON, self.clearFunc )

    #def OnNewFrame(self, evt):
    #    self.frame2 = self.res.LoadFrame(None, 'nextFrame')
    #    self.frame2.Show()


if __name__ == '__main__':
    app = MyApp(False)
    app.MainLoop()

test.xrc

<?xml version="1.0" encoding="UTF-8" standalone="yes" ?>
<resource xmlns="http://www.wxwindows.org/wxxrc" version="2.3.0.1">
    <object class="wxFrame" name="mainFrame">
        <style>wxDEFAULT_FRAME_STYLE|wxTAB_TRAVERSAL</style>
        <size>500,300</size>
        <title></title>
        <centered>1</centered>
        <object class="wxBoxSizer">
            <orient>wxVERTICAL</orient>
            <object class="sizeritem">
                <option>0</option>
                <flag>wxEXPAND</flag>
                <border>5</border>
                <object class="wxBoxSizer">
                    <minsize>-1,80</minsize>
                    <orient>wxHORIZONTAL</orient>
                    <object class="sizeritem">
                        <option>0</option>
                        <flag>wxEXPAND</flag>
                        <border>5</border>
                        <object class="wxBoxSizer">
                            <minsize>100,-1</minsize>
                            <orient>wxVERTICAL</orient>
                            <object class="sizeritem">
                                <option>0</option>
                                <flag>wxALL</flag>
                                <border>5</border>
                                <object class="wxStaticBitmap" name="m_bitmap1">
                                    <bitmap />
                                </object>
                            </object>
                        </object>
                    </object>
                    <object class="sizeritem">
                        <option>1</option>
                        <flag>wxEXPAND</flag>
                        <border>5</border>
                        <object class="wxBoxSizer">
                            <orient>wxVERTICAL</orient>
                            <object class="sizeritem">
                                <option>0</option>
                                <flag>wxALL|wxALIGN_CENTER_HORIZONTAL</flag>
                                <border>5</border>
                                <object class="wxStaticText" name="titleText">
                                    <font>
                                        <size>30</size>
                                        <family>default</family>
                                        <style>normal</style>
                                        <weight>normal</weight>
                                        <underlined>0</underlined>
                                        <face>Verdana Bold</face>
                                    </font>
                                    <label>TITLE</label>
                                    <wrap>-1</wrap>
                                </object>
                            </object>
                        </object>
                    </object>
                    <object class="sizeritem">
                        <option>0</option>
                        <flag>wxEXPAND</flag>
                        <border>5</border>
                        <object class="wxBoxSizer">
                            <minsize>100,-1</minsize>
                            <orient>wxVERTICAL</orient>
                            <object class="sizeritem">
                                <option>1</option>
                                <flag>wxEXPAND</flag>
                                <border>5</border>
                                <object class="wxBoxSizer">
                                    <orient>wxVERTICAL</orient>
                                    <object class="sizeritem">
                                        <option>0</option>
                                        <flag>wxALL</flag>
                                        <border>5</border>
                                        <object class="wxStaticBitmap" name="m_bitmap2">
                                            <bitmap />
                                        </object>
                                    </object>
                                </object>
                            </object>
                            <object class="sizeritem">
                                <option>1</option>
                                <flag>wxEXPAND</flag>
                                <border>5</border>
                                <object class="wxBoxSizer">
                                    <orient>wxVERTICAL</orient>
                                    <object class="sizeritem">
                                        <option>0</option>
                                        <flag>wxALL</flag>
                                        <border>5</border>
                                        <object class="wxStaticBitmap" name="m_bitmap3">
                                            <bitmap />
                                        </object>
                                    </object>
                                </object>
                            </object>
                        </object>
                    </object>
                </object>
            </object>
            <object class="sizeritem">
                <option>1</option>
                <flag>wxEXPAND</flag>
                <border>5</border>
                <object class="wxBoxSizer">
                    <orient>wxVERTICAL</orient>
                    <object class="sizeritem">
                        <option>1</option>
                        <flag>wxALIGN_CENTER_HORIZONTAL</flag>
                        <border>5</border>
                        <object class="wxFlexGridSizer">
                            <rows>2</rows>
                            <cols>2</cols>
                            <vgap>0</vgap>
                            <hgap>0</hgap>
                            <growablecols></growablecols>
                            <growablerows></growablerows>
                            <object class="sizeritem">
                                <option>0</option>
                                <flag>wxALL</flag>
                                <border>5</border>
                                <object class="wxStaticText" name="envLabel">
                                    <font>
                                        <size>20</size>
                                        <family>default</family>
                                        <style>normal</style>
                                        <weight>normal</weight>
                                        <underlined>0</underlined>
                                        <face>Calibri Bold</face>
                                    </font>
                                    <label>List1</label>
                                    <wrap>-1</wrap>
                                </object>
                            </object>
                            <object class="sizeritem">
                                <option>0</option>
                                <flag>wxALL</flag>
                                <border>5</border>
                                <object class="wxChoice" name="list1">
                                    <selection>0</selection>
                                    <content>
                                        <item>val1</item>
                                        <item>val2</item>
                                        <item>val3</item>
                                    </content>
                                </object>
                            </object>
                            <object class="sizeritem">
                                <option>0</option>
                                <flag>wxALL</flag>
                                <border>5</border>
                                <object class="wxStaticText" name="serviceLabel">
                                    <font>
                                        <size>20</size>
                                        <family>default</family>
                                        <style>normal</style>
                                        <weight>normal</weight>
                                        <underlined>0</underlined>
                                        <face>Calibri Bold</face>
                                    </font>
                                    <label>List2</label>
                                    <wrap>-1</wrap>
                                </object>
                            </object>
                            <object class="sizeritem">
                                <option>0</option>
                                <flag>wxALL</flag>
                                <border>5</border>
                                <object class="wxChoice" name="list2">
                                    <selection>0</selection>
                                    <content>
                                        <item>val4</item>
                                        <item>val5</item>
                                        <item>val6</item>
                                    </content>
                                </object>
                            </object>
                        </object>
                    </object>
                    <object class="sizeritem">
                        <option>1</option>
                        <flag>wxALIGN_CENTER_HORIZONTAL</flag>
                        <border>5</border>
                        <object class="wxBoxSizer">
                            <orient>wxHORIZONTAL</orient>
                            <object class="sizeritem">
                                <option>0</option>
                                <flag>wxALL</flag>
                                <border>5</border>
                                <object class="wxButton" name="Button1">
                                    <font>
                                        <family>default</family>
                                        <style>normal</style>
                                        <weight>normal</weight>
                                        <underlined>0</underlined>
                                        <face>Cambria Bold</face>
                                    </font>
                                    <label>Start</label>
                                    <default>0</default>
                                </object>
                            </object>
                            <object class="sizeritem">
                                <option>0</option>
                                <flag>wxALL</flag>
                                <border>5</border>
                                <object class="wxButton" name="Button2">
                                    <font>
                                        <family>default</family>
                                        <style>normal</style>
                                        <weight>normal</weight>
                                        <underlined>0</underlined>
                                        <face>Calibri Bold</face>
                                    </font>
                                    <label>Stop</label>
                                    <default>0</default>
                                </object>
                            </object>
                        </object>
                    </object>
                </object>
            </object>
        </object>
    </object>
</resource>