How to and what responce Client expected from server

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My server program in vb6 successfully getting data from client ( Biochemistry analyser operating software). Data came is in duplicates i.e same data again send by client this happen when client give error. " LIS responce timed out". So I think when client is not getting server responce then send data again. Data send was like below

MSH|^~\&|Factory|Chemistry Analyzer|||20210430190330||ORU^R01|9|P|2.3.1||||0||ASCII|||
PID|9||||shitalPL||||||||||||||||||||||||||
OBR|1||11|Factory^Chemistry Analyzer|N||20210430183639||||||||Serum|||||||||||||||||||||||||||||||||
OBX|1|NM|GLU|GLU|198.452857|mg/dL|-|Normal|||F||198.452857|20210430183639||||

As I get above data. Then what responce I should send to client and How?

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