How to Check intersection between two images on a specific location?

Question

How can I check intersection between two images on a specific location in the second image.

For example:

There's Image 1 and Image 2.

I want to know if Image 1 intersects with Image 2 IN a specific location.

Here's the image for example :

I want to check if Image 1 intersects with the white part in this object.

How can I make this work?

Thanks in advance.