I've been told that defragging causes the log to grow tremendously. Is this true? If so, is there something better to do than defragging that will not impact the log as much? We are running SQL Server 2005 replicating between 2 sites.
Is defragging tough on replication?
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There is no 'defrag' in SQL Server. You may be talking about an index reorganize operation or an index rebuild operation. Reorganize is light on log, but index rebuild creates as much log as the size of the index multiplied by a factor. For a large index the rebuild operation may result in log growth.
Having a large log will impact the transactional log reader agent simply because it will have more log records to scan through for a period. Eventually the log reader agent will catch up. The exact numbers (duration of latency, latency size etc) will differ based on a number of factors, your best choice is trial and measurement.
As for alternatives:
If the answers are Yes, Yes and Yes and the conclusion is that periodic index rebuild is unavoidable then there is no alternative, you're going to have to bite the bullet and take this operation into account when calibrating the hardware requirements.