I guess you can't make a signature in Mail using AppleScript anymore?
If you're running Sierra, give this simple script a try:
tell application "Mail" to make new signature with properties {name:"My Signature"}
All I get is "Mail got an error. AppleEvent handler failed."
Is this a bug?
It appears that the "AppleEvent handler failed" error occurs on many other occasions when running AppleScript on MacOs Sierra. I cannot delete mailboxes for instance: applescript can't delete any mailbox