ASP.NET site memory use up to 99% if IIS app pool NOT enable 32-bit applications

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We have a ASP.NET MVC3 site on a 8GB memory Windows server 2019, when I enable 32bit applications on of IIS app pool, the site running well, cpu and memory use(about 300MB) of w3wp.exe also low and noraml. But if I disable 32bit applications of IIS app pool, the memory use will rise to 99%. Anyone knows why? I dumped memory when up to 99% by perfview, it says System.Globalization object consumed the memory, but I'm not sure. Please help, Thanks in advance! memory dump

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