Conda UnsatisfiableError (for antibody humanization)

Question

I am trying to run biophi in anaconda to humanize antibodies (https://github.com/Merck/BioPhi). I am very new to this so already after trying to get biophi running I encounter the following error.

UnsatisfiableError: The following specifications were found to be incompatible with each other:

Output in format: Requested package -> Available versions

The following specifications were found to be incompatible with your system:

  - feature:/win-64::__win==0=0
  - feature:|@/win-64::__win==0=0
  - biophi -> click[version='>=7'] -> __unix
  - biophi -> click[version='>=7'] -> __win

Your installed version is: 0

Thank you in advance!

I tried installing click using pip install click, which seems to work, but doesnt resolve the error message. I am running this in windows and not in unix/linux.

Answer 1

The defined software environment ultimately depends on hmmer, which is only available through Bioconda and only supports Linux and macOS.

Windows users who wish to use Bioconda have the option of either using WSL2 to run Linux or a container system, like Docker. You will need to install a Linux version of Conda base in the subsystem/container. I recommend Miniforge to all bioinformaticians.