convert multidimensional nd array from uint16 to int16

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When I read an 16 bit tiff (gray scale image having two dimension) image using scipy, and check its dtype using image.dtype I get uint16 (Uint16 is unassigned 16 bit integer). I want int16 to work further in my code. Could you please give a quick method to convert from uint16 type nd array int16 nd array

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