Importance Of Document Continuity & Chapter Interrelationships

Question

If I have a large document, such as a book, with chapters that build on and reference each other, do I lose their interrelationships by breaking up the document? I am working in the Lite version and am curious as to whether to break up a large pdf into smaller doc or pdf files or to keep it intact. The limitation on the number of characters (50,000) may drive me to another plan.