After a restart ADS will clear all servers/queries. There is a save all option but this is not efficient when it must go through often 50+ servers, saving them as separate files.
Essentially I want to reopen my entire workspace on start (all servers and queries I was working on), can I do this?
This link may answer your question...
https://www.aquaclusters.com/app/home/project/public/aquadatastudio/wikibook/New-Features-10.0/page/2/5-Autosave-Workspace
Disclaimer: I'm not an active user of AquaData Studio; this is just what I found on a quick search.