Is it possible to change data in an open worksheet through modules, openpyxl, xlsxwriter, xlwt, or xlutils?

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I need to modify the data of the excel cells without it being closed, is this a limitation of the modules or is it possible to do this process? Python returns this error: '' PermissionError: [Errno 13] Permission denied: 'sample.xlsx' '' . Can someone help me ?print

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