Python - using .isin() in pandas with the negator ~

Question

Edit: Figured it out. Thanks.

I think I must have missed something in my studies and I'm hoping you can help explain. I'm working on a case study and the following line is used to subset the semi-cleaned df to remove the values in the nonBoroughs list from the column London_Boroughs.

NaNFreeDF2[~NaNFreeDF2.London_Borough.isin(nonBoroughs)]

The two things I'm not understanding are:

1. Why is it '~' instead of '!' for the not operator? or is '~' an entirely different operator in pandas?

2. Why is the above code used instead of NaNFreeDF2[NaNFreeDF2['London_Borough'] != nonBoroughs]] ? Is the above just a more advanced way of doing it that I haven't learned yet?

Thanks in advance!