I have a system of equations with 800 unknowns in the form of the equation Ku=F (the dimensions of the matrix K are 800*800 and naturally the dimensions of the two matrices u and F will be 800*1) where some of the unknowns are in the matrix F and some of the unknowns in is the matrix u. Solving this system of equations with the solve command is very time-consuming (approximately 3 and a half hours). Is there a way to put all the unknowns on one side and use the LUsolve command?
Or in general, is there a way to solve this system of equations faster?
(Numb library is for numerical solution and could not be used in sympy)
import sympy as sy
K = sy.Matrix(Components) #800*800
u = sy.Matrix(Components) #800*1
F = sy.Matrix(Components) #800*1
answer = sy.solve(sy.Eq(K*u,F))

I can't offer much in the way of mathematical tweaks to speed up your solution. However, if you need to do heavy computational lifting, sympy is generally not your friend. Sympy was made to be easy to use, not to be performant. Unless you find the mathematical shortcut you're looking for (and maybe even if you do) the best advice I can offer is to look into different CAS engines. SymEngine is one that can serve as a (mostly) drop-in replacement for sympy if you need to stick with Python. If you have freedom to look outside of Python, you might consider Sage, Mathematica, and MATLAB. Any of these will outperform sympy by a very significant margin.