To run nodejs file on a real domain

Question

Citations: To run nodejs file on my domain

Is there a way to do like this?

npm run app.js --someAction? realdomain.com:80

• my case is just to run a simple single file.
• don't want use any web server Apache or nginx.
• don't want any env file.
• don't want change /etc/hosts.
• and there is no way to change client side /etc/hosts.