I am currently working on Umbraco Upgrade.
My Current version of Umbraco is 7.2.8 and I want to upgrade it to 7.3.0.
I have upgraded successfully but now i am trying to execute project it shows me below error :
Is there anything that have to be changed in database? Because i have upgraded via nuget.
Please help me out from this situation.

1) In the web.config try to set the umbracoConfigurationStatus to emty, this will force a upgrade process:
2) In the Web.config check the umbracoDbDSN connectionstring. If you use a .sdf file check if the file exists. Else check the connection.
3) Your database file is corrupted. restore the .sdf file from a backup, or try the repair tool. http://sqlcecmd.codeplex.com/ see https://technet.microsoft.com/en-us/library/ms172420.aspx
Or the database file is locked or somethings by another process, restart the computer