I just downloaded and installed Xcode 5 GM seed. I removed the previous Xcode (DP5). When I open my project, select "iPhone Retina (4-inch 64 bit)" and type Command-U to run my SenTeskingKit unit tests, Xcode invariably complains:
"Simulator in Use - The Simulator can't be launched because it is already in use."
I have run xcode-select to point to the new Xcode, restarted my MacBookPro, and made sure there are no other iPhone sim processes running under the Activity Monitor.
Simply click on Quit Xcode from the editor menu of Xcode and open Xcode again. You will get the simulator.